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20 records – page 1 of 1.

Fundamentals of cancer detection

https://bccalibrary.andornot.com/en/permalink/catalog125334
De, Surya K. Weinheim, Germany: Wiley-VCH , 2022.
Audience
Professional
Content:; Front Matter -- An Overview of Cancer -- Cancer Risk Factors and Prevention -- Bladder Cancer -- Cancers of the Blood -- Brain and Spinal Cord Tumors -- Breast Cancer -- Colorectal Cancer -- Cervical Cancer -- Kidney Cancer -- Liver (Hepatocellular) Cancer -- Lung Cancer -- Melanoma (Skin…
  1 read online  
Author
De, Surya K.
Place of Publication
Weinheim, Germany
Publisher
Wiley-VCH
Publication Date
2022
Series
Proquest Ebook Central
Subjects
Neoplasms
Neoplasms - diagnosis
Neoplasms - prevention & control
Neoplasms - therapy
Abstract
Content:
Front Matter -- An Overview of Cancer -- Cancer Risk Factors and Prevention -- Bladder Cancer -- Cancers of the Blood -- Brain and Spinal Cord Tumors -- Breast Cancer -- Colorectal Cancer -- Cervical Cancer -- Kidney Cancer -- Liver (Hepatocellular) Cancer -- Lung Cancer -- Melanoma (Skin Cancer) -- Mesothelioma -- Ovarian, Vaginal, and Vulvar Cancer -- Pancreatic Cancer -- Prostate Cancer -- Stomach (Gastric) Cancer -- Thyroid Cancer -- Endometrial Cancer -- Penile Cancer -- Testicular Cancer -- Index
ISBN
9783527838585
9783527350650
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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Diagnosis and treatment

https://bccalibrary.andornot.com/en/permalink/catalog16188
World Health Organization. Geneva: World Health Organization , 2008.
Audience
Professional
Call Number
QZ200 C219w 2007 v.4
Availability
1 copy, 1 available
  1 read online  
Alternate Title
Cancer control : knowledge into action : WHO guide for effective programmes : diagnosis and treatment
Corporate Author
World Health Organization
Place of Publication
Geneva
Publisher
World Health Organization
Publication Date
2008
Physical Description
vi, 42 p. : ill. ; 26 cm.
Series
Cancer control : knowledge into action : WHO guide for effective programmes module 4
Subjects
Neoplasms - diagnosis
Neoplasms - therapy
National Health Programs
Early Diagnosis
Patients
Guideline
ISBN
9789241547406
9241547406
Language
English
Material Type
Book
Audience
Professional
Location
Vancouver Library
Call Number
QZ200 C219w 2007 v.4
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c.1 BC Cancer Agency VAN Library Available
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Examining disparities in cancer control : a system performance special focus report. February 2014

https://bccalibrary.andornot.com/en/permalink/catalog114781
Canadian Partnership Against Cancer. [Toronto, ON]: Canadian Partnership Against Cancer , 2014.
Audience
Professional
Call Number
QZ200 C212e 2014
Availability
1 copy, 1 available
  2 read online  
Corporate Author
Canadian Partnership Against Cancer
Place of Publication
[Toronto, ON]
Publisher
Canadian Partnership Against Cancer
Publication Date
2014
Physical Description
83 p. : ill. ; 29 cm.
Series
System performance reports
Subjects
Neoplasms - epidemiology
Neoplasms - prevention & control
Risk Factors
Health Planning
Population Surveillance
Healthcare Disparities
Health Status Disparities
Health Policy
Health Services Needs and Demand
Delivery of Health Care
Cultural Diversity
Health Services Accessibility
Socioeconomic Factors
Canada
Language
English
Material Type
Report
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ200 C212e 2014
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c.1 BC Cancer Agency VAN Library Available
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Metis cancer control in Canada baseline report

https://bccalibrary.andornot.com/en/permalink/catalog121143
Canadian Partnership Against Cancer. [Toronto, ON]: Canadian Partnership Against Cancer , 2014.
Audience
Professional
Call Number
QZ200 C212m 2014
Availability
1 copy, 1 available
  2 read online  

World cancer report 2008

https://bccalibrary.andornot.com/en/permalink/catalog17717
International Agency for Research on Cancer. Lyon, France: IARC Press , 2008.
Audience
Professional
Availability
1 copy, 1 available
  1 read online  
Corporate Author
International Agency for Research on Cancer
Editor
Boyle, Peter
Levin, Bernard
Place of Publication
Lyon, France
Publisher
IARC Press
Publication Date
2008
Subjects
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - prevention & control
Neoplasms - therapy
World Health
Statistics
ISBN
9789283204237
9283204239
Language
English
Material Type
Book
Online
Audience
Professional
Location
Internet
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c.1 BC Cancer Agency VAN Library Available
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Cancer control 2014 : cancer care in emerging heath systems

https://bccalibrary.andornot.com/en/permalink/catalog21695
International Network for Cancer Treatment and Research. Suffolk, UK: Global Health Dynamics | International Network for Cancer Treatment and Research , 2014.
Audience
Professional
Call Number
QZ200 C2125 2014
Availability
1 copy, 1 available
Building capacity for cancer treatment in low-income countries with particular reference to East Africa by Ian Magrath and Simon Sutcliffe.
  1 read online  
Corporate Author
International Network for Cancer Treatment and Research
Editor
Magrath, Ian
Place of Publication
Suffolk, UK
Publisher
Global Health Dynamics
International Network for Cancer Treatment and Research
Publication Date
2014
Physical Description
152 p. : ill. ; 30 cm.
Subjects
Neoplasms - epidemiology
Neoplasms - prevention & control
Neoplasms - therapy
Early Detection of Cancer
Health Planning
Health Promotion
Health Policy
Health Services Accessibility
Health Care Facilities, Manpower, and Services
Mass Screening
Population Surveillance
Developing Countries
World Health
Abstract
Building capacity for cancer treatment in low-income countries with particular reference to East Africa by Ian Magrath and Simon Sutcliffe.
ISBN
9780957607217
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ200 C2125 2014
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c.1 BC Cancer Agency VAN Library Available
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Investment in cancer risk and prevention research 2005-2007 : a special report from the Canadian Cancer Research Alliance's survey of government and voluntary sector investment in cancer research

https://bccalibrary.andornot.com/en/permalink/catalog18860
Canadian Cancer Research Alliance. [Toronto, ON]: Canadian Cancer Research Alliance (CCRA) , 2010.
Audience
Patient or Public
Call Number
QZ206 C215c 2010
Availability
1 copy, 1 available
This report focuses on investment in research focused on cancer risk and prevention over a three-year period. Research is critiical to our understanding of cancer risk and effective cancer prevention strategies. The investment in cancer risk and prevention at $122.3M represented 11% of the overal…
  2 read online  
Corporate Author
Canadian Cancer Research Alliance
Place of Publication
[Toronto, ON]
Publisher
Canadian Cancer Research Alliance (CCRA)
Publication Date
2010
Physical Description
53 p. : ill. ; 28 cm.
Subjects
Neoplasms - economics
Neoplasms - prevention & control
Research
Research Support as Topic
Investments - statistics & numerical data
Financing, Organized
Canada
Statistics
Abstract
This report focuses on investment in research focused on cancer risk and prevention over a three-year period. Research is critiical to our understanding of cancer risk and effective cancer prevention strategies. The investment in cancer risk and prevention at $122.3M represented 11% of the overall investment in cancer research form 2005-07.
ISSN
9780978415761 (print)
9780978415778 (PDF)
Language
English
Material Type
Serial
Report
Online
Audience
Patient or Public
Location
Vancouver Library
Internet
Call Number
QZ206 C215c 2010
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Copies

c.1 BC Cancer Agency VAN Library Available
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Health state descriptions for Canadians : cancers

https://bccalibrary.andornot.com/en/permalink/catalog15691
[Ottawa, ON]: Statistics Canada , 2006.
Audience
Professional
Call Number
QZ200 H434e 2006
Availability
1 copy, 1 available
The series is primarily intended to document the disease classifications used in the Population Health Impact of Disease in Canada (PHI) research program and help researchers to understand how the PHI estimates were calculated. It is also of interest to health professionals, advocacy groups, and in…
  1 read online  
Editor
Evans, William K
Place of Publication
[Ottawa, ON]
Publisher
Statistics Canada
Publication Date
2006
Series
Health state descriptions for Canadians
Subjects
Neoplasms - psychology
Neoplasms - diagnosis
Neoplasms - epidemiology - Canada
Neoplasms - rehabilitation
Neoplasms - therapy
Neoplasm Staging
Activities of Daily Living
Health Status - Canada
Cost of Illness - Canada
Quality of Life
Risk Factors
Prognosis
Attitude to Health
Classification and Measurement System of Functional Health (CLAMES)
Abstract
The series is primarily intended to document the disease classifications used in the Population Health Impact of Disease in Canada (PHI) research program and help researchers to understand how the PHI estimates were calculated. It is also of interest to health professionals, advocacy groups, and individual Canadians who are looking for an overview of how living with cancer affects day-to-day functioning throughout its various stages of progression and treatment."
ISBN
0662696182
ISSN
1718-4630
Language
English
French
Material Type
Book
Audience
Professional
Location
Vancouver Library
Call Number
QZ200 H434e 2006
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c.1 BC Cancer Agency VAN Library Available
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Cognition and cancer

https://bccalibrary.andornot.com/en/permalink/catalog18468
New York, NY: Cambridge University Press , 2008.
Audience
Professional
Call Number
QZ266 C676 2008
Availability
1 copy, 1 available
Clinical neuropsychology by Jill B. Rich and Angela K. Troyer; Brain imaging investigation of chemotherapy-induced neurocognitive changes by Brenna C. McDonald, Andrew J. Saykin, and Tim A. Ahles; Role of neuropsychological assessment in cancer patients by Elana Farace; Neuropsychological assessmen…
  1 read online  
Editor
Meyers, Christina A
Perry, James R
Place of Publication
New York, NY
Publisher
Cambridge University Press
Publication Date
2008
Physical Description
xii, 341 p. : ill. ; 26 cm.
Series
Proquest Ebook Central
Subjects
Neoplasms - complications
Neoplasms - therapy
Cognition Disorders - etiology
Cognition Disorders - diagnosis
Antineoplastic Agents - adverse effects
Neuropsychological Tests
Abstract
Clinical neuropsychology by Jill B. Rich and Angela K. Troyer
Brain imaging investigation of chemotherapy-induced neurocognitive changes by Brenna C. McDonald, Andrew J. Saykin, and Tim A. Ahles
Role of neuropsychological assessment in cancer patients by Elana Farace
Neuropsychological assessment of adults with cancer by Anne E. Kayl, Robert Collins, and Jeffrey S. Wefel
Neuropsychological assessment of children with cancer by Louise Penkman Fennell and Robert W. Butler
Biological bases of radiation injury to the brain by Edward G. Shaw and Mike E. Robbins
Cognitive dysfunction related to chemotherapy and biological response modifiers by Jeffrey S. Wefel, Robert Collins, and Anne E. Kayl
Effect of hormones and hormonal treatment on cognition by Christien Schilder, Sanne Schagen, and Frits Van Dam
Low-grade gliomas by Martin J. B. Taphoorn and Charles G. Niel
High-grade gliomas by Michael J. Glantz and John W. Conlee
Brain metastases by Deepak Khuntia ... [et al.]
Primary central nervous system lymphoma by Denise D. Correa
Childhood brain tumors by H. Stacy Nicholson, Louise Penkman Fennell, and Robert W. Butler
Neurofibromatosis by Bartlett D. Moore III and John M. Slopis
Hematological malignancies by Melissa Friedman and Mercedes Fernandez
Paraneoplastic disorders by Edward Dropcho
Symptomatic therapies and supportive care issues by Alan Valentine and Eduardo Bruera
Animal models and cancer-related symptoms by Adrian Dunn
Behavioral strategies and rehabilitation by Dona E.C. Locke, Jane H. Cerhan, and James F. Malec
Support services by Bebe Guill and Renee H. Raynor
Pharmacological interventions for the treatment of radiation-induced brain injury by Edward G. Shaw ... [et al.]
Neurocognitive testing in clinical trials by Jennifer A. Smith and Jeffrey S. Wefel
ISBN
9780521854825
0521854822
Language
English
Material Type
Book
Ebook
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ266 C676 2008
Website Notes
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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Copies

c.1 BC Cancer Agency VAN Library Available
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Investment in cancer risk and prevention research 2005-2010 : a special report from the Canadian Cancer Research Alliance's survey of government and voluntary sector investment in cancer research : June 2013

https://bccalibrary.andornot.com/en/permalink/catalog21199
Canadian Cancer Research Alliance. [Toronto, ON]: Canadian Cancer Research Alliance (CCRA) , 2013.
Audience
Patient or Public
Call Number
QZ206 C215cj 2013
Availability
1 copy, 1 available
  2 read online  
Corporate Author
Canadian Cancer Research Alliance
Place of Publication
[Toronto, ON]
Publisher
Canadian Cancer Research Alliance (CCRA)
Publication Date
2013
Physical Description
59 p. : ill. ; 28 cm.
Subjects
Neoplasms - economics
Neoplasms - prevention & control
Biomedical Research - economics
Research
Research Support as Topic
Investments - statistics & numerical data
Financing, Organized
Canada
Statistics
ISSN
9781927650066 (print)
9781927650073 (PDF)
Language
English
Material Type
Serial
Book
Online
Audience
Patient or Public
Location
Vancouver Library
Call Number
QZ206 C215cj 2013
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c.1 BC Cancer Agency VAN Library Available
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Progress report on cancer control in Canada

https://bccalibrary.andornot.com/en/permalink/catalog13586
Canada. Health Canada. Population and Public Health Branch. Centre for Chronic Disease Prevention and Control. [Ottawa, ON]: Health Canada , 2004.
Audience
Patient or Public
Call Number
QZ200 P963 2004
Availability
3 copies, 3 available
  1 read online  
Corporate Author
Canada. Health Canada. Population and Public Health Branch. Centre for Chronic Disease Prevention and Control
Place of Publication
[Ottawa, ON]
Publisher
Health Canada
Publication Date
2004
Subjects
Neoplasms - prevention & control
Canada
ISBN
0662377257
Language
English
Material Type
Book
Audience
Patient or Public
Location
Vancouver Library
Kelowna Library
Victoria Library
Call Number
QZ200 P963 2004
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c.2 BC Cancer Agency VAN Library Available
c.1 BC Cancer Agency VIC Library Available
c.1 BC Cancer Agency KEL Library Available
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Starving cancer cells : evidence based strategies to slow cancer progression : a selection of readings for health services providers

https://bccalibrary.andornot.com/en/permalink/catalog123711
Fried, Robert, Carlton, Richard M., Fried, Dennis A. London, UK: Academic Press , 2021.
Audience
Professional
  1 read online  
Author
Fried, Robert
Carlton, Richard M.
Fried, Dennis A.
Place of Publication
London, UK
Publisher
Academic Press
Publication Date
2021
Series
EBSCOhost eBook
Subjects
Neoplasms - therapy
Neoplasms - prevention & control
Technology
ISBN
9780128240137
9780128241349
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This EBSCO title is licensed for one BC Cancer staff user at a time only. Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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Prostate cancer control in Canada : a system performance spotlight report

https://bccalibrary.andornot.com/en/permalink/catalog120280
Canadian Partnership Against Cancer. [Toronto, ON]: Canadian Partnership Against Cancer , 2015.
Audience
Professional
Call Number
WJ752 C212 2015
Availability
1 copy, 1 available
  2 read online  
Alternate Title
Head of title: System performance reports
Corporate Author
Canadian Partnership Against Cancer
Place of Publication
[Toronto, ON]
Publisher
Canadian Partnership Against Cancer
Publication Date
2015
Physical Description
124 p. : ill. ; 29 cm.
Series
System performance reports
Subjects
Prostatic Neoplasms - prevention & control
Quality of Health Care
Canada
Notes
November 2015
ISBN
9781988000015
9781988000008
Language
English
Material Type
Report
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
WJ752 C212 2015
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c.1 BC Cancer Agency VAN Library Available
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Cancer control interventions in selected jurisdictions : design, governance, and implementation : monograph

https://bccalibrary.andornot.com/en/permalink/catalog16504
Caron, Lorraine. Montreal, QC: AETMIS , 2008.
Audience
Professional
  2 read online  
Alternate Title
Comparative overview of cancer control strategies in selected jurisdictions
Author
Caron, Lorraine
Place of Publication
Montreal, QC
Publisher
AETMIS
Publication Date
2008
Physical Description
353 p.
Subjects
Neoplasms - prevention & control
Canada
England
France
New Zealand
ISBN
9782550525974 (print)
9782550525974 (PDF)
Language
English
Material Type
Book
Online
Audience
Professional
Location
Internet
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Breast cancer control in Canada : a system performance special focus report

https://bccalibrary.andornot.com/en/permalink/catalog113935
Canadian Partnership Against Cancer. [Toronto, ON]: Canadian Partnership Against Cancer , 2012.
Audience
Professional
  2 read online  
Corporate Author
Canadian Partnership Against Cancer
Place of Publication
[Toronto, ON]
Publisher
Canadian Partnership Against Cancer
Publication Date
2012
Physical Description
iii, 114 p. : ill. ; 28 cm.
Series
System performance reports
Subjects
Breast Neoplasms - prevention & control
Quality of Health Care
Canada
Notes
September 2012
Language
English
Material Type
Report
Online
Audience
Professional
Location
Internet
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Breast cancer : guidelines for the pathological examination and reporting of breast specimens

https://bccalibrary.andornot.com/en/permalink/catalog18242
Canada. Health Canada. [Ottawa, ON]: Minister of Public Works and Government Services Canada , 2002.
Audience
Professional
Call Number
WP870 B826c 2002
  1 read online  
Corporate Author
Canada. Health Canada
Place of Publication
[Ottawa, ON]
Publisher
Minister of Public Works and Government Services Canada
Publication Date
2002
Physical Description
1v.
Subjects
Breast Neoplasms - pathology
Breast Neoplasms - prevention & control
Checklist
Practice Guideline
Canada
ISBN
0662669118 (print)
0662327225
Language
English
French
Material Type
Book
Online
Audience
Professional
Location
Internet
Call Number
WP870 B826c 2002
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Cancer, nutrition, and eating behavior : a biobehavioral perspective

https://bccalibrary.andornot.com/en/permalink/catalog123240
New York, NY: Routledge , 2021.
Audience
Professional
"The majority of cancer-related deaths are associated with nutritional problems. The major role that nutrition and diet play in the development and course of cancer had only been recently appreciated, and relatively little had been written on the topic in general. A critical component of nutrition …
  1 read online  
Editor
Burish, Thomas G.
Levy, Sandra M.
Meyerowitz, Beth E.
Place of Publication
New York, NY
Publisher
Routledge
Publication Date
2021
Series
Proquest Ebook Central
Psychology revivals
Subjects
Diet
Feeding Behavior - drug effects
Feeding Behavior - radiation effects
Neoplasms - etiology
Neoplasms - therapy
Nutrition Disorders - etiology
Congress
Abstract
"The majority of cancer-related deaths are associated with nutritional problems. The major role that nutrition and diet play in the development and course of cancer had only been recently appreciated, and relatively little had been written on the topic in general. A critical component of nutrition and diet is eating behavior. Originally published in 1985, the purpose of this book was to meet the needs of both the clinician and the researcher by bringing together data and theory about nutrition and cancer from several disciplines, as considered from a biobehavioral perspective. The first chapter of the book provides an overview of the purposes and organization of the volume. The rest is divided into 3 parts. Part 1 focuses on basic research concerned with the nature and development of taste aversions and taste preferences in human and animals. Part 2 applies the basic processes reviews in the first part to the cancer area, focusing on eating and nutritional problems related to both tumor development and to learned processes that develop as a result of being exposed to radiotherapy and chemotherapy treatments. Part 3 focuses on identifying and evaluating intervention strategies for improving the nutritional status of people with cancer or at high risk for developing cancer. - Provided by publisher
Notes
This book was first published in 1985 by Lawrence Erlbaum Associates, Inc. and is based on a conference held at Vanderbilt University in Mar. 1983.
ISBN
9780367620868
9781000326482
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This title is licensed for one user at a time on BC Cancer network computer. If you are denied access while on a network computer, try again later.
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted
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Precision cancer medicine : role of the pathologist

https://bccalibrary.andornot.com/en/permalink/catalog123749
Jasani, Bharat. Cham, Switzerland: Springer , 2021.
Audience
Professional
This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artif…
  1 read online  
Author
Jasani, Bharat
Place of Publication
Cham, Switzerland
Publisher
Springer
Publication Date
2021
Series
Proquest Ebook Central
Subjects
Precision Medicine
Neoplasms - therapy
Neoplasms - pathology
Neoplasms - etiology
Abstract
This book describes the changing role of pathology in aiding reproducible and accurate patient selection for predictive cancer therapy. Particular attention is given to the clinical application of cutting-edge cancer biomarkers to accurately select patients for targeted cancer therapy and how artificial intelligence can improve the precision of treatments. The advent and basis of predictive cancer care, the role of pathologists in translational cancer research, the analysis of cancer samples, the management of biopsy results, and the accuracy of biopsy results are also discussed. Precision Cancer Medicine: Role of the Pathologist details how pathologists can use the latest biomarkers and apply artificial intelligence technology in cancer diagnosis and management. It is also relevant to oncologists and medical practitioners involved in cancer management seeking an up-to-date resource on the topic. -- Provided by publisher.
ISBN
9783030840877
9783030840860
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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How plant flavonoids affect the outcome of hormonal and biological cancer therapies : a handbook for doctors and patients

https://bccalibrary.andornot.com/en/permalink/catalog124273
Sak, Katrin. New York, NY: Nova Science Publishers, Inc. , 2022.
Audience
Patient or Public
  1 read online  
Author
Sak, Katrin
Place of Publication
New York, NY
Publisher
Nova Science Publishers, Inc.
Publication Date
2022
Series
Proquest Ebook Central
Cancer etiology, diagnosis and treatments
Subjects
Neoplasms - therapy
Neoplasms - prevention & control
Flavonoids - therapeutic use
Nutrition Therapy
Popular Work
ISBN
9781685076085
9781685076986
Language
English
Material Type
Ebook
Audience
Patient or Public
Location
Internet
Website Notes
Patients and the public of BC and the Yukon can access this title by emailing library@bccancer.bc.ca or calling 1.888.675.8001 x 7000 (toll-free) to obtain a username and password.
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BC Generations Project

https://bccalibrary.andornot.com/en/permalink/catalog18161
BC Generations Project. [Vancouver, BC?]: BC Generations Project , 2009?.
Audience
Patient or Public
  1 read online  
Alternate Title
BC Healthbank
Corporate Author
BC Generations Project
Place of Publication
[Vancouver, BC?]
Publisher
BC Generations Project
Publication Date
2009?
Subjects
Neoplasms - prevention & control
Chronic Disease - prevention & control
Biomedical Research
Epidemiology
Epidemiologic Studies
British Columbia
Canada
Language
English
Material Type
Handout
Online
Audience
Patient or Public
Location
Vancouver Library Pamphlet File
Internet
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20 records – page 1 of 1.