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Understanding cancer : the molecular mechanisms, biology, pathology and clinical implications of malignant neoplasia

https://bccalibrary.andornot.com/en/permalink/catalog125356
Tarin, David. Cham, Switzerland: Springer , 2023. 1st ed.
Audience
Professional
This book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biolo…
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Author
Tarin, David
Edition
1st ed.
Place of Publication
Cham, Switzerland
Publisher
Springer
Publication Date
2023
Series
Proquest Ebook Central
Subjects
Neoplasms
Neoplasms - genetics
Neoplasms - microbiology
Neoplasms - pathology
Abstract
This book provides a unique, wide-ranging description of the phenomenon of cancer and its pathological effects in diverse species including humans, domesticated and wild animals, invertebrates, and plants. The broad scope of information presented is used to construct radical new insights into biological self-regulation and explain their relevance to its disruption by cancerous growth and spread within the human body. Mechanisms of action of carcinogenic agents, initiation, progression, metastasis, inappropriate gene expression, dormancy, latency, regression, and reasons for susceptibility and/or resistance to cancer are all considered. Also discussed are criteria for pathological diagnosis, advances in treatment, implications for public health, and pitfalls in diagnosis and interpretation of experimental results. The book describes operational mechanisms of cancer at the levels of whole individual, organ, tissue, cell, molecular, and even atomic (quantum) scales of structural and physiological order. Evidence is assembled from all these levels of organization to show that cancer is a dynamically changing disorder and that it is an inherent and perpetual risk of multicellular composition. This provides pragmatic new biological and clinical perspectives on malignant neoplasia. The biological insight is that it is a consequence of progressing miscommunication within a cellular society. The clinical perspective is realistic but optimistic in reasoning that, although cancer can never be completely eradicated from human life, because it is a disorder of our intrinsic biological constitution, it can be controlled and ameliorated and even cured in a proportion of individuals. The text is profusely illustrated with over 300 macroscopic and microscopic pictures. It will stimulate curiosity and interest specialists, as well as beginners, in many scientific disciplines and provides copious references to the medical and scientific literature supporting its conclusions. Readers from fields as diverse as medicine, pathology, veterinary sciences, cell biology, molecular biology, developmental biology, and epidemiology will find the information the book contains thought-provoking, interesting, and useful. Additionally, specialists in occupational and environmental health and legal experts focusing on exposure to carcinogenic materials and pollution will find the contents valuable and informative.
ISBN
9783030973933
9783030973926
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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Human genome structure, function and clinical considerations

https://bccalibrary.andornot.com/en/permalink/catalog123234
Cham, Switzerland: Springer Nature Switzerland AG , 2021.
Audience
Professional
Contents:; Chapter 1: An Overview of the Human Genome -- Chapter 2: Human Chromosomes -- Chapter 3: Methods to Study Genomic DNA Sequence Variation -- Chapter 4: Protein-Coding Genes -- Chapter 5: Noncoding Gene Families of the Human Genome -- Chapter 6: Satellite and Tandem DNA Repeats in the Huma…
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Editor
Haddad, Luciana Amaral
Place of Publication
Cham, Switzerland
Publisher
Springer Nature Switzerland AG
Publication Date
2021
Series
Proquest Ebook Central
Subjects
Genome, Human
Genetics, Human
Genomics
Abstract
Contents:
Chapter 1: An Overview of the Human Genome -- Chapter 2: Human Chromosomes -- Chapter 3: Methods to Study Genomic DNA Sequence Variation -- Chapter 4: Protein-Coding Genes -- Chapter 5: Noncoding Gene Families of the Human Genome -- Chapter 6: Satellite and Tandem DNA Repeats in the Human Genome --Chapter 7: Human Chromosome Telomeres -- Chapter 8: To Build or To Break: The Dual Impact of Interspersed Transposable Elements in Cancer -- Chapter 9: Copy Number Variation in the Human Genome -- Chapter 10: The Human Mitochondrial DNA -- Chapter 11: Population Variation of the Human Genome.
ISBN
9783030731502
9783030731519
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This title is licensed for one user at a time on BC Cancer network computer. If you are denied access while on a network computer, try again later.
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
Read Online
https://login.bccancer.idm.oclc.org/login?url=https://ebookcentral.proquest.com/lib/bccancer-ebooks/detail.action?docID=6638839
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Fast facts : comprehensive genomic profiling

https://bccalibrary.andornot.com/en/permalink/catalog123247
Rapoport, Bernardo, Troncone, Giancarlo, Schmitt, Fernando, Nayler, Simon. Abingdon, UK: S. Karger Publishers Ltd. , 2020.
Audience
Professional
Contents:; 1: GENETIC MUTATIONS AND BIOMARKERS -- 2: UNDERSTANDING NEXT-GENERATION SEQUENCING -- 3: ELEMENTS OF COMPREHENSIVE GENOMIC PROFILES -- 4: ROLE IN PRECISION ONCOLOGY -- 5: PREDICTIVE AND PROGNOSTIC BIOMARKERS -- 6: OVERCOMING BARRIERS TO GENOTYPE-DIRECTED THERAPY
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  1 read online  
Author
Rapoport, Bernardo
Troncone, Giancarlo
Schmitt, Fernando
Nayler, Simon
Place of Publication
Abingdon, UK
Publisher
S. Karger Publishers Ltd.
Publication Date
2020
Series
R2 Library
Fast facts (UK)
Subjects
Genome, Human
Genetics, Human
Genomics
Abstract
Contents:
1: GENETIC MUTATIONS AND BIOMARKERS -- 2: UNDERSTANDING NEXT-GENERATION SEQUENCING -- 3: ELEMENTS OF COMPREHENSIVE GENOMIC PROFILES -- 4: ROLE IN PRECISION ONCOLOGY -- 5: PREDICTIVE AND PROGNOSTIC BIOMARKERS -- 6: OVERCOMING BARRIERS TO GENOTYPE-DIRECTED THERAPY
ISBN
3318068187
9783318068184
9783318068191
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This R2 title is licensed for one BC Cancer staff user at a time only. Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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https://login.bccancer.idm.oclc.org/login?url=https://www.r2library.com/Resource/Title/3318068187
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Principles of cancer genetics

https://bccalibrary.andornot.com/en/permalink/catalog125338
Bunz, Fred. Cham, Switzerland: Springer Nature Switzerland AG , 2022. 3rd ed.
Audience
Professional
Content:; 1: The Genetic Basis of Cancer -- 2: Oncogenes -- 3: Tumor Suppressor Genes -- 4: Genetic Instability and Cancer -- 5: Cancer Genomes -- 6: Cancer Gene Pathways -- 7: Cancer and the Immune System -- 8: Common Cancers and Their Genetic Alterations -- 9: Cancer Detection and Prognostication…
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  1 read online  
Author
Bunz, Fred
Edition
3rd ed.
Place of Publication
Cham, Switzerland
Publisher
Springer Nature Switzerland AG
Publication Date
2022
Series
Proquest Ebook Central
Subjects
Neoplasms - genetics
Genomics
Oncogenes
Abstract
Content:
1: The Genetic Basis of Cancer -- 2: Oncogenes -- 3: Tumor Suppressor Genes -- 4: Genetic Instability and Cancer -- 5: Cancer Genomes -- 6: Cancer Gene Pathways -- 7: Cancer and the Immune System -- 8: Common Cancers and Their Genetic Alterations -- 9: Cancer Detection and Prognostication -- 10: Cancer Therapy
ISBN
9783030993870
9783030993863
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
Read Online
https://login.bccancer.idm.oclc.org/login?url=https://ebookcentral.proquest.com/lib/bccancer-ebooks/detail.action?docID=7021737
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Diagnostic genetic testing : core concepts and the wider context for human DNA analysis

https://bccalibrary.andornot.com/en/permalink/catalog123671
Bourn, David. Cham, Switzerland: Springer Publishing Company, LLC , 2022.
Audience
Professional
Contents:; Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: G…
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  1 read online  
Author
Bourn, David
Place of Publication
Cham, Switzerland
Publisher
Springer Publishing Company, LLC
Publication Date
2022
Series
R2 Library
Subjects
Genetic Testing
Genetic Carrier Screening
Genome, Human
Genome - genetics
Abstract
Contents:
Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: Genome-Scale Testing -- DNA Testing: Pulling the Strands Together.
ISBN
3030855090
9783030855093
9783030855109
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This R2 title is licensed for one BC Cancer staff user at a time only. Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
Read Online
https://login.bccancer.idm.oclc.org/login?url=https://www.r2library.com/Resource/Title/3030855090
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