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Chimeric antigen receptor t-cell therapies for cancer : a practical guide

https://bccalibrary.andornot.com/en/permalink/catalog122174

Cambridge, MA: Elsevier, Inc. , 2020.

Audience: Professional

Call Number: QZ266 C538 2020

Availability: 3 copies, 3 available

Contents:; Introduction -- When to refer a patient for CAR-T cell therapy -- Optimizing the apheresis product -- CAR T cells: cell processing laboratory considerations -- Peri-CAR-T cell management -- Management of cytokine release syndrome -- Special considerations for ICU management of patients r…

Editor: Lee, Daniel W.; Shah, Nirali N.

Place of Publication: Cambridge, MA

Publisher: Elsevier, Inc.

Publication Date: 2020

Physical Description: xiv, 229 p. : ill. ; 24 cm.

Subjects: Neoplasms - therapy; Receptors, Chimeric Antigen - therapeutic use; Receptors, Antigen, T-Cell; Immunotherapy, Adoptive - methods; Cell- and Tissue-Based Therapy

Abstract: Contents:; Introduction -- When to refer a patient for CAR-T cell therapy -- Optimizing the apheresis product -- CAR T cells: cell processing laboratory considerations -- Peri-CAR-T cell management -- Management of cytokine release syndrome -- Special considerations for ICU management of patients receiving CAR therapy -- Neurotoxicities after CAR-T cell immunotherapy -- Hematologic and non-CRS toxicities -- Response assessment and post-CAR-T cell therapy management -- Relapse management and role for consolidative hematopoietic stem cell transplantation following CAR-T cell therapy -- Promising chimeric antigen receptors for non-B cell hematological malignancies, pediatric solid tumors, and carcinomas -- CAR T cell therapy for CNS malignancies -- CAR 2.0: the next generation of synthetic receptor-based cellular therapy for cancer.