Editor

Lee, Daniel W.

Shah, Nirali N.

Place of Publication

Cambridge, MA

Publisher

Elsevier, Inc.

Publication Date

2020

Physical Description

xiv, 229 p. : ill. ; 24 cm.

Subjects

Neoplasms - therapy

Receptors, Chimeric Antigen - therapeutic use

Receptors, Antigen, T-Cell

Immunotherapy, Adoptive - methods

Cell- and Tissue-Based Therapy

Abstract

Contents:

Introduction -- When to refer a patient for CAR-T cell therapy -- Optimizing the apheresis product -- CAR T cells: cell processing laboratory considerations -- Peri-CAR-T cell management -- Management of cytokine release syndrome -- Special considerations for ICU management of patients receiving CAR therapy -- Neurotoxicities after CAR-T cell immunotherapy -- Hematologic and non-CRS toxicities -- Response assessment and post-CAR-T cell therapy management -- Relapse management and role for consolidative hematopoietic stem cell transplantation following CAR-T cell therapy -- Promising chimeric antigen receptors for non-B cell hematological malignancies, pediatric solid tumors, and carcinomas -- CAR T cell therapy for CNS malignancies -- CAR 2.0: the next generation of synthetic receptor-based cellular therapy for cancer.

ISBN

9780323661812

Language

English

Material Type

Book

Audience

Professional

Location

Vancouver Library

Abbotsford Library

Victoria Library

Call Number

QZ266 C538 2020

Copies

Author

Abbas, Abul K.

Lichtman, Andrew H.

Pillai, Shiv

Edition

10th ed.

Place of Publication

Philadelphia, PA

Publisher

Elsevier Inc.

Publication Date

[2022]

Physical Description

xii, 587 p. : col. ill. : 28 cm.

Subjects

Immunity, Cellular

Antibody Formation - immunology

Antigens - immunology

Immunologic Diseases - immunology

Lymphocytes - immunology

Abstract

Contents:

Properties and Overview of Immune Responses -- Cells and Tissues of the Immune System -- Leukocyte Circulation and Migration into Tissues -- Innate Immunity -- Antibodies and Antigens -- Antigen Presentation to T Lymphocytes and the Functions of MHC Molecules -- Immune Receptors and Signal Transduction -- Lymphocyte Development and Antigen Receptor Gene Rearrangement -- Activation of T Lymphocytes -- Differentiation and Functions of CD4+ Effector T Cells -- Differentiation and Functions of CD8+ Effector T Cells -- B Cell Activation and Antibody Production -- Effector Mechanisms of Humoral Immunity -- Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues -- Immunologic Tolerance and Autoimmunity -- Immunity to Microbes -- Transplantation Immunology -- Immunity to Tumors -- Hypersensitivity Disorders -- Allergy -- Congenital and Acquired Immunodeficiencies

ISBN

9780323757485

Language

English

Material Type

Book

Audience

Professional

Location

Vancouver Library

Call Number

QW568 A122c 2022

Copies