Editor

Baiocchi, Marta

Place of Publication

New York, NY

Publisher

Humana Press

Publication Date

2022

Physical Description

xiii, 242 p. : col. ill. ; 26 cm.

Series

Methods in molecular biology 2535

Subjects

Drug Resistance, Neoplasm

Antineoplastic Agents - therapeutic use

ISBN

9781071625125

ISSN

1064-3745

1940-6029

Language

English

Material Type

Book

Audience

Professional

Location

Vancouver Library

Call Number

QZ267 C2187b 2022

Copies

Editor

Malviya, Rishabha

Singh, Arun Kumar

Yadav, Deepika

Edition

1st ed.

Place of Publication

Beverly, MA

Publisher

Scrivener Publishing

Publication Date

c2023

Series

Proquest Ebook Central

Subjects

Chemotherapy

Drug Resistance, Neoplasm

Abstract

"The book details the mechanisms underlying multi-drug cellular resistance and the targets of novel chemotherapeutic agents.

Cancer is a major killer all over the world. Even with all the progress made, chemotherapy is still the mainstay of modern cancer treatment. The progression of the cellular defeat of numerous independent anticancer drugs in terms of their chemical structure is a major barrier to successful chemotherapy. Multi-drug resistance (MDR) is a term for the fact that most cancer patients exhibit this phenomenon. According to the numbers, drug resistance carries the blame for 90% of cancer patient deaths. Refractory cancer and tumor recurrence are common outcomes of prolonged chemotherapy. Because of the prevalence of drug-resistance mutations, the difficulty of treating tumors increases and the therapeutic efficacy of drugs decreases.

Multi-Drug Resistance in Cancer: Mechanism and Treatment Strategies contains nine chapters that cover topics such as: studying the mechanics of resistance to drugs by autophagy; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; advances in metallodrug driven combination treatment for cancer; and use of natural agents for the overcoming of cancer drug resistance.

The book aims to provide the latest data on the mechanisms of cellular resistance to anticancer agents currently used in clinical treatment. It provides a better understanding of the mechanisms of MDR and targets of novel chemotherapy agents which should guide future research concerning new effective strategies in cancer treatment.

Audience

This book is written for pharmaceutical and biomedical scientists and researchers at both the bench and in the clinic who are interested in the mechanisms and strategies for overcoming cancer's multi-drug resistance." --publisher

ISBN

9781394209217

Language

English

Material Type

Ebook

Audience

Professional

Location

Internet

Website Notes

This title is licensed for one user at a time on BC Cancer-network computers. If you are denied access while on a network computer, try again later.

This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.

Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.