The BC Cancer Library
Delivering timely service and evidence-informed resources to people in BC and the Yukon facing cancer and those involved in oncology care or research.
Delivering timely service and evidence-informed resources to people in BC and the Yukon facing cancer and those involved in oncology care or research.
Age of cancer incidence; Multistage progression; History of theories; Progression dynamics; Theory I; Theory II; Genetics of progression; Carcinogens; Aging; Inheritance; Stem cells : tissue renewal; Stem cells : population genetics; Cell lineage history
Contents:; 1: GENETIC MUTATIONS AND BIOMARKERS -- 2: UNDERSTANDING NEXT-GENERATION SEQUENCING -- 3: ELEMENTS OF COMPREHENSIVE GENOMIC PROFILES -- 4: ROLE IN PRECISION ONCOLOGY -- 5: PREDICTIVE AND PROGNOSTIC BIOMARKERS -- 6: OVERCOMING BARRIERS TO GENOTYPE-DIRECTED THERAPY
Table of contents:; The evolution of lifespans and disease avoidance -- Understanding evolution at organismal and somatic levels -- The evolution of multicellularity and tumor suppression -- Mechanisms of tumor suppression -- Dominant views on the mechanisms of oncogenesis -- Adaptive oncogenesis -…
Table of Contents:; The Human Genome: Foundation for Genomic and Precision Medicine -- The Functional Genome: Epigenetics and Epigenomics -- The State of Whole-Genome Sequencing -- The Human Microbiome -- Quantitative Proteomics for Clinical Translation -- From Data to Knowledge: An Introduction to…
Contents:; Chapter 1: An Overview of the Human Genome -- Chapter 2: Human Chromosomes -- Chapter 3: Methods to Study Genomic DNA Sequence Variation -- Chapter 4: Protein-Coding Genes -- Chapter 5: Noncoding Gene Families of the Human Genome -- Chapter 6: Satellite and Tandem DNA Repeats in the Huma…
Contents:; DNA structure and function -- Protein synthesis -- Genetic influences on cell division, cell differentiation, and gametogenesis -- Patterns of inheritance -- Epigenetic influences on gene expression -- Autosomal inheritance and disorders -- Sex chromosome and mitochondrial inheritance di…
Table of Contents:; Risk Assessment for Breast Cancer -- Genetic Evaluation for Women at Increased Risk -- Imaging Screening and Surveillance -- Risk-Reducing Surgery for BRCA1/2 Genetic Mutation Carriers -- Prophylactic Oophorectomy for Patients with Germline BRCA Mutations -- Pathology of BRCA Tu…
Contents:; Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: G…
"A key resource for all genetic counselors and other healthcare providers, this comprehensive reference has been completely updated and reorganized for its fourth edition; Over 50 hereditary cancer predisposition genes have now been identified. Genetic testing can be a powerful tool in assessing in…
Contents:; Systematic Review as a Basis for Evidence Based Practice -- The Value of Systematic Review : Dispelling Myths -- Organizing and Planning a Systematic Review -- Steps in the Systematic Review Process -- Developing Clinical Questions for a Systematic Review -- Resources and Methods to Maxi…
Table of Contents:; PART I. Introduction -- 1.Systematic Review as the Basis for Evidence-Based Practice -- 2. Steps in the Systematic Review Process -- PART II. A Framework for Conducting Systematic Reviews-- 3. Planning and Organizing a Systematic Review -- 4. Developing Clinical Questions for Sy…
