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20 records – page 1 of 1.

Therapeutic Approaches in Cancer Treatment

https://bccalibrary.andornot.com/en/permalink/catalog124717
Cham, Switzerland: Springer International Publishing AG , c2023. 1st ed.
Audience
Professional
"This comprehensive book provides an overview of cancer therapeutics and covers different innovative treatment approaches for cancer. The initial chapter gives a detailed overview on cancer progression and disease diagnostics. The following chapters focus on different cancer treatment approaches, s…
More Information
  1 read online  
Editor
Qazi, Asma Saleem
Tariq, Kanwal
Edition
1st ed.
Place of Publication
Cham, Switzerland
Publisher
Springer International Publishing AG
Publication Date
c2023
Series
Proquest Ebook Central
Subjects
Neoplasms - therapy
Therapeutics
Drug Therapy
Hormones
Radiotherapy
Immunotherapy
Nutrition Assessment
Antineoplastic Agents
Pharmacogenomic Variants
Abstract
"This comprehensive book provides an overview of cancer therapeutics and covers different innovative treatment approaches for cancer. The initial chapter gives a detailed overview on cancer progression and disease diagnostics. The following chapters focus on different cancer treatment approaches, such as chemotherapy, radiotherapy, hormonal therapy, immunotherapy, nutritional assessments, targeted therapy and Nano therapeutics. It also highlights the importance of cancer genomics, disease advancement, personalized medicine and psychological support for cancer patients. Emphasis is also given to the many challenges in the area of designing cancer treatment and designing clinical trials. The complete book also presents cancer management with different cancer treatment modalities, including pharmacogenomics and drug reactions. This is a unique and comprehensive piece of work that not only highlights the disease treatment modalities but also focuses on many challenges in the area of designing cancer treatment and even in designing clinical trials.
The contributing authors are experts in this field of cancer treatment. By familiarizing readers with the latest developments in this complex field, the book offers a valuable resource for clinicians. Researchers and medical students will also benefit from this comprehensive text." --publisher
ISBN
9783031271557
Language
English
Material Type
Ebook
Audience
Professional
Location
Internet
Website Notes
This title is licensed for one user at a time on BC Cancer-network computers. If you are denied access while on a network computer, try again later.
This Proquest title is licensed for ONE BC Cancer staff user at a time. If you are denied access while on a network computer, please try again later.
Authentication via HealthBC sign in required. Use your BC Cancer staff username and ID when prompted.
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https://login.bccancer.idm.oclc.org/login?url=https://ebookcentral.proquest.com/lib/bccancer-ebooks/detail.action?docID=30592740
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Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures

https://bccalibrary.andornot.com/en/permalink/catalog18163
International Agency for Research on Cancer, World Health Organization. Lyon, France: International Agency for Research on Cancer , 2010.
Audience
Professional
Call Number
QZ202 I585 2010 v.92
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
World Health Organization
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2010
Physical Description
viii, 853 p. : ill. ; 24 cm.
Series
IARC monographs on the evaluation of carcinogenic risks to humans 92
Subjects
Carcinogens
Environmental Pollutants - toxicity
Neoplasms - etiology
Polycyclic Hydrocarbons, Aromatic - toxicity
Risk Assessment - methods
DNA Adducts
Environmental Exposure
Occupational Exposure
ISBN
9789283212928
ISSN
1017-1606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2010 v.92
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol92/mono92.pdf
http://monographs.iarc.fr/ENG/Monographs/PDFs/index.php

Copies

c.1 BC Cancer Agency VAN Library Available
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Red meat and processed meat

https://bccalibrary.andornot.com/en/permalink/catalog120904
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, France: International Agency for Research on Cancer , 2018.
Audience
Professional
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 6-13 October 2015
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2018
Series
IARC monographs on the evaluation of carcinogenic risks to humans 114
Subjects
Carcinogens
Red Meat - adverse effects
Food Additives - adverse effects
Diet, Western - adverse effects
Risk Factors
Abstract
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 6-13 October 2015
ISBN
9789283201809
ISSN
1017-1606
Language
English
Material Type
Book
Online
Serial
Audience
Professional
Location
Internet
Website Notes
Available in PDF format.
Read Online
https://monographs.iarc.fr/monographs-and-supplements-available-online/
https://monographs.iarc.fr/wp-content/uploads/2018/06/mono114.pdf
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Man-made vitreous fibres

https://bccalibrary.andornot.com/en/permalink/catalog10319
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 2002.
Audience
Professional
Call Number
QZ202 I585 2002 v.81
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2002
Series
IARC monographs on the evaluation of carcinogenic risks to humans 81
Subjects
Mineral Fibers
Neoplasms - chemically induced
Occupational Exposure
Risk Assessment
Carcinogens
ISBN
9283212819
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2002 v.81
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol81/index.php
http://monographs.iarc.fr/ENG/Monographs/vol81/mono81.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Smokeless tobacco and some tobacco-specific N-nitrosamines

https://bccalibrary.andornot.com/en/permalink/catalog16184
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004 October 5-12 : Lyon, France), World Health Organization. Lyon, France: International Agency for Research on Cancer , 2007.
Audience
Professional
Call Number
QZ202 I585 2007 v.89
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2004 October 5-12 : Lyon, France)
World Health Organization
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2007
Physical Description
ix, 626 p. : ill. ; 24 cm.
Series
IARC monographs on the evaluation of carcinogenic risks to humans 89
Subjects
Tobacco, Smokeless - adverse effects
Carcinogens
Nitrosamines - adverse effects
Risk Assessment
ISBN
9789283212898
ISSN
1017-1606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2007 v.89
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol89/index.php
http://monographs.iarc.fr/ENG/recentpub/mono89.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Chemicals, industrial processes and industries associated with cancer in humans

https://bccalibrary.andornot.com/en/permalink/catalog13997
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1982.
Audience
Professional
Call Number
QZ202 I585 1982 Suppl 4
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1982
Series
IARC monographs on the evaluation of carcinogenic risks to humans suppl 4
Subjects
Neoplasms - genetics
Carcinogens
ISBN
9283214064
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1982 Suppl 4
Read Online
http://monographs.iarc.fr/ENG/Monographs/suppl4/index.php
http://monographs.iarc.fr/ENG/Monographs/suppl4/Suppl4.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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1,3-Butadiene, ethylene oxide, and vinyl halides (vinyl flouride, vinyl chloride, and vinyl bromide)

https://bccalibrary.andornot.com/en/permalink/catalog20440
International Agency for Research on Cancer, World Health Organization. Lyon, France: International Agency for Research on Cancer , 2008.
Audience
Professional
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
World Health Organization
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2008
Physical Description
ix, 510 p. ; ill. ; 24 cm.
Series
IARC monographs on the evaluation of carcinogenic risks to humans 97
Subjects
Carcinogens
Butadienes - adverse effects
Ethylene Oxide - adverse effects
Vinyl Compounds - adverse effects
Neoplasms - chemically induced
Risk Assessment
ISBN
9789283212973
9283212975
ISSN
1017-1606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Internet
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol97/index.php
http://monographs.iarc.fr/ENG/Monographs/vol97/mono97.pdf
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Printing processes and printing inks, carbon black and some nitro compounds

https://bccalibrary.andornot.com/en/permalink/catalog808
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1996.
Audience
Professional
Call Number
QZ202 I585 1996 v.65
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1996
Series
IARC monographs on the evaluation of carcinogenic risks to humans 65
Subjects
Carcinogens
Neoplasms - chemically induced
Ink - adverse effects
ISBN
9283212657
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1996 v.65
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol65/index.php
http://monographs.iarc.fr/ENG/Monographs/vol65/mono65.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Some non-nutritive sweetening agents

https://bccalibrary.andornot.com/en/permalink/catalog18674
International Agency for Research on Cancer, IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Lyon, France: International Agency for Research on Cancer , 1980.
Audience
Professional
Call Number
QZ202 I585 1980 v.22
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1980
Series
IARC monographs on the evaluation of carcinogenic risks to humans 22
Subjects
Carcinogens
Neoplasms - chemically induced
Sweetening Agents - toxicity
ISBN
9789283212225
9283212223
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1980 v.22
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol1-42/index.php
http://monographs.iarc.fr/ENG/Monographs/vol1-42/mono22.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Some pharmaceutical drugs

https://bccalibrary.andornot.com/en/permalink/catalog18675
International Agency for Research on Cancer, IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Lyon, France: International Agency for Research on Cancer , 1980.
Audience
Professional
Call Number
QZ202 I585 1980 v.24
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Man
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1980
Series
IARC monographs on the evaluation of carcinogenic risks to humans 24
Subjects
Carcinogens
Neoplasms - chemically induced
Drug Therapy - adverse effects
ISBN
9789283212249
928321224X
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1980 v.24
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol1-42/index.php
http://monographs.iarc.fr/ENG/Monographs/vol1-42/mono24.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Hormonal contraception and post-menopausal hormonal therapy

https://bccalibrary.andornot.com/en/permalink/catalog3851
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1999.
Audience
Professional
Call Number
QZ202 I585 1999 v.72
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1999
Subjects
Carcinogens
Hormones - adverse effects
Estrogen Replacement Therapy - adverse effects
Contraception, Oral - adverse effects
ISBN
928321072X
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1999 v.72
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol72/index.php
http://monographs.iarc.fr/ENG/Monographs/vol72/mono72.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Cancer atlas

https://bccalibrary.andornot.com/en/permalink/catalog123276
Atlanta, GA: American Cancer Society , 2019. 3rd ed.
Audience
Patient or Public
More Information
  2 read online  
Editor
Jemal, Ahmedin
Torre, Lindsey
Soerjomataram, Isabelle
Bray, Freddie
Edition
3rd ed.
Place of Publication
Atlanta, GA
Publisher
American Cancer Society
Publication Date
2019
Subjects
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms
Neoplasms - prevention & control
Carcinogens
Global Burden of Disease
Delivery of Health Care
Risk Factors
Atlases
ISBN
9781604432657
Language
English
Material Type
Book
Online
Audience
Patient or Public
Location
Internet
Read Online
http://canceratlas.cancer.org/
https://canceratlas.cancer.org/wp-content/uploads/2019/10/ACS_CA3_Book.pdf
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Overall evaluations of carcinogenicity : an updating of IARC monographs : volumes 1 to 42

https://bccalibrary.andornot.com/en/permalink/catalog4729
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1987.
Audience
Professional
Call Number
QZ202 I585 1987 Suppl 7
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1987
Series
IARC monographs on the evaluation of carcinogenic risks to humans suppl 7
Subjects
Carcinogens
Neoplasms - etiology
ISBN
9283214410
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1987 Suppl 7
Read Online
http://monographs.iarc.fr/ENG/Monographs/suppl7/index.php
http://monographs.iarc.fr/ENG/Monographs/suppl7/Suppl7.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone

https://bccalibrary.andornot.com/en/permalink/catalog114755
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, France: International Agency for Research on Cancer , 2016.
Audience
Professional
This publication represents the views and expert; opinions of an IARC Working Group on the; Evaluation of Carcinogenic Risks to Humans which met in Lyon (France) June 3 -10, 2014.
More Information
  1 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2016
Series
IARC monographs on the evaluation of carcinogenic risks to humans 110
Subjects
Carcinogens
Neoplasms - chemically induced
Abstract
This publication represents the views and expert
opinions of an IARC Working Group on the
Evaluation of Carcinogenic Risks to Humans which met in Lyon (France) June 3 -10, 2014.
ISSN
1017-1606
Language
English
French
Material Type
Book
Online
Audience
Professional
Location
Internet
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol110/index.php
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Some industrial chemicals

https://bccalibrary.andornot.com/en/permalink/catalog5628
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1994.
Audience
Professional
Call Number
QZ202 I585 1994 v.60
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1994
Series
IARC monographs on the evaluation of carcinogenic risks to humans 60
Subjects
Carcinogens
Neoplasms - chemically induced
ISBN
9283212606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 1994 v.60
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol60/index.php
http://monographs.iarc.fr/ENG/Monographs/vol60/mono60.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Some industrial chemicals

https://bccalibrary.andornot.com/en/permalink/catalog9455
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 2000.
Audience
Professional
Call Number
QZ202 I585 2000 v.77
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2000
Series
IARC monographs on the evaluation of carcinogenic risks to humans 77
Subjects
Carcinogens
Neoplasms - chemically induced
ISBN
9283212770
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2000 v.77
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol77/index.php
http://monographs.iarc.fr/ENG/Monographs/vol77/mono77.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Some thyrotropic agents

https://bccalibrary.andornot.com/en/permalink/catalog9782
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 2001.
Audience
Professional
Call Number
QZ202 I585 2001 v.79
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2001
Series
IARC monographs on the evaluation of carcinogenic risks to humans 79
Subjects
Thyroid Neoplasms - chemically induced
Carcinogens
ISBN
9283212797
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2001 v.79
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol79/index.php
http://monographs.iarc.fr/ENG/Monographs/vol79/mono79.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Man-made mineral fibres and radon

https://bccalibrary.andornot.com/en/permalink/catalog8443
International Agency for Research on Cancer. Lyon, France: International Agency for Research on Cancer , 1988.
Audience
Professional
Call Number
QZ202 I585 v.43
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
1988
Series
IARC monographs on the evaluation of carcinogenic risks to humans 43
Subjects
Carcinogens
Radon
Fibers
Neoplasms - etiology
ISBN
9283212436
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 v.43
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol43/index.php
http://monographs.iarc.fr/ENG/Monographs/vol43/mono43.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Human papillomaviruses

https://bccalibrary.andornot.com/en/permalink/catalog16348
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2005 February 15-22 : Lyon, France), World Health Organization. Lyon, France: International Agency for Research on Cancer , 2007.
Audience
Professional
Call Number
QZ202 I585 2007 v.90
Availability
1 copy, 1 available
More Information
  2 read online  
Corporate Author
International Agency for Research on Cancer
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2005 February 15-22 : Lyon, France)
World Health Organization
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2007
Physical Description
viii, 670 p. : ill. ; 24 cm.
Series
IARC monographs on the evaluation of carcinogenic risks to humans 90
Subjects
Papillomavirus Infections
Papillomaviridae - pathogenicity
Tumor Virus Infections - etiology
Genital Neoplasms, Female - virology
Uterine Cervical Neoplasms - virology
Carcinogens
ISBN
9789283212904
ISSN
1017-1606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Internet
Call Number
QZ202 I585 2007 v.90
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol90/index.php
http://monographs.iarc.fr/ENG/recentpub/mono90.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
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Review of human carcinogens : Part D : radiation

https://bccalibrary.andornot.com/en/permalink/catalog20443
International Agency for Research on Cancer, World Health Organization. Lyon, France: International Agency for Research on Cancer , 2012.
Audience
Professional
Call Number
QZ202 I585 2012 v.100D
Availability
2 copies, 2 available
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 2-9 June, 2009.
More Information
  2 read online  
Alternate Title
Radiation
Corporate Author
International Agency for Research on Cancer
World Health Organization
Place of Publication
Lyon, France
Publisher
International Agency for Research on Cancer
Publication Date
2012
Physical Description
vii, 341 p. : ill. ; 27 cm.
Series
IARC monographs on the evaluation of carcinogenic risks to humans 100D
Subjects
Carcinogens
Neoplasms - etiology
Radiation - adverse effects
Abstract
This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, which met in Lyon, 2-9 June, 2009.
ISBN
9789283213215
ISSN
1017-1606
Language
English
Material Type
Book
Online
Audience
Professional
Location
Vancouver Library
Victoria Library
Internet
Call Number
QZ202 I585 2012 v.100D
Read Online
http://monographs.iarc.fr/ENG/Monographs/vol100D/index.php
http://monographs.iarc.fr/ENG/Monographs/vol100D/mono100D.pdf

Copies

c.1 BC Cancer Agency VAN Library Available
c.1 BC Cancer Agency VIC Library Available
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20 records – page 1 of 1.