Editor

Emanuel, Ezekiel J

Place of Publication

New York, NY

Publisher

Oxford University Press

Publication Date

2008

Physical Description

xx, 827 p. : ill. ; 29 cm.

Subjects

Human Experimentation - ethics

Ethics, Research

Ethics Committees, Research

Research Subjects - legislation & jurisprudence

Abstract

I: Selected history of research with humans

Walter Reed and the yellow fever experiments by Susan E. Lederer

Nazi medical experiments by Paul J. Weindling

Imperial Japanese experiments in China by Takashi Tsuchiya

Randomized controlled trial of streptomycin by Alan Yoshioka

Salk polio vaccine field trial of 1954 by Marcia L. Meldrum

Jewish chronic disease hospital case by John D. Arras

Hepatitis experiments at the Willowbrook State School by Walter M. Robinson and Brandon T. Unruh

Tuskegee syphilis experiment by James H. Jones

HIV research by John Y. Killen Jr.

Gelsinger case by Robert Steinbrook II: Codes, declarations, and other ethical guidance for research with humans

Ethical framework for biomedical research by Ezekiel J. Emanuel, David Wendler and Christine Grady

Nuremberg code by George J. Annas and Michael A. Grodin

Declaration of Helsinki by Richard E. Ashcroft

Belmont report by Tom L. Beauchamp

Regulations for the protection of humans in research in the United States: The common rule by Joan P. Porter and Greg Koski

International ethical guidance rrom the Council for International Organizations of Medical Sciences by Juhana E. ldanpaan-Heikkila and Sev S. Fluss

Council of Europe by Peteris Zilgalvis

European Community directives on data protection and clinical trials by Deryck Beyleveld and Sebastian Sethe

National bioethics commissions and research ethics by Eric M. Meslin and Summer Johnson III. Context, purpose, and value of clinical research

Exploitation in clinical research by Alan Wertheimer

Nature, scope, and justification of Clinical Research : what Is research? Who Is a subject? by Robert J. Levine

Four paradigms of clinical research and research oversight by Ezekiel J. Emanuel and Christine Grady

Role of patient advocates and public representatives in research by Rebecca Dresser IV. Scientific design

Equipoise and randomization by Steven Joffe and Robert D. Truog

Ethics of placebo-controlled trials by Franklin G. Miller

Challenge experiments by Franklin G. Miller and Donald L. Rosenstein

Emergency research by Jason H. T. Karlawish

Research with biological samples by David Wendler

Genetic diagnostic, pedigree, and screening research by Eric T. Juengst and Aaron Goldenberg

Deception in clinical research by David Wendler and Franklin G. Miller

Epidemiology : observational studies on human populations by Douglas L. Weed and Robert E. McKeown

Behavioral and social science research by Felice J. Levine and Paula R. Skedsvold

Phase I Oncology research by Manish Agrawal and Ezekiel J. Emanuel

Surgical innovation and research by Grant R. Gillett V. Participant selection Sect. A. Fair Participant selection

What Is fair participant selection? by Leslie A. Meltzer and James F. Childress

Incentives for research participants by Neal Dickert and Christine Grady

Recruiting research participants by Franklin G. Miller

Sect. B. Special populations

Research involving women by Christine Grady and Colleen Denny

Research with ethnic and minority populations by Bernard Lo and Nesrin Garan

Research involving economically disadvantaged participants by Carol Levine

Research involving those at risk for impaired decision-making capacity by Donald L. Rosenstein and Franklin G. Miller

Research with children by Alan R. Fleischman and Lauren K. Collogan

Research with captive populations :prisoners, students, and soldiers by Valerie H. Bonham and Jonathan D. Moreno

Research with identifiable and targeted communities by Morris W. Foster and Richard R. Sharp

Research with healthy volunteers by Albert R. Jensen and Franklin G. Miller

Research with fetuses, embryos, and stem cells by Ronald M. Green VI. Risk-benefit assessments

Risk-benefit analysis and the net risks test by David Wendler and Franklin G. Miller

Assessing and comparing potential benefits and risks of harm by Nancy M. P. King and Larry R. Churchill

Risk-benefit assessment in pediatric research by Sumeeta Varma and David Wendler VII. Independent review and oversight

Origins and policies that govern institutional review boards by Charles R. McCarthy

Models of institutional review board function by Angela J. Bowen

Evaluating the effectiveness of institutional review boards by Marjorie A. Speers

Data and safety monitoring boards by Lawrence M. Friedman and Eleanor B. Schron

Food and drug administration and drug development : historic, scientific, and ethical considerations by Robert Temple and Sara F. Goldkind VIII. Informed consent

History of informed consent in clinical research by Erika Blacksher and Jonathan D. Moreno

Philosophical justifications of informed consent in research by Dan W. Brock

Legal and regulatory standards of informed consent in research by Alexander M. Capron

Therapeutic misconception by Paul S. Appelbaum and Charles W. Lidz

Empirical issues in informed consent for research by James H. Flory, David Wendler and Ezekiel J. Emanuel

Assent requirement in pediatric research by David Wendler IX. Respect for human research participants

Confidentiality by James G. Hodge Jr. and Lawrence O. Gostin

Liability and compensation for injury of research subjects by Wendy K. Mariner

Obligation to ensure access to beneficial treatments for research participants at the conclusion of clinical trials by James V. Lavery X. Multinational research

Appropriate ethical standards by Ruth Macklin

Benefits to host countries by Ezekiel J. Emanuel

Standard of care in multinational research by Soren Holm and John Harris

Responsiveness to host community health needs by Alex John London XI. Clinical investigator behavior

Conflict of interest in medical research : historical developments by Trudo Lemmens

Concept of conflicts of interest by Ezekiel J. Emanuel and Dennis F. Thompson

Empirical data on donflicts of interest by Lindsay A. Hampson, Justin E. Bekelman and Cary P. Gross

Industrialization of academic science and threats to scientific integrity by Eric G. Campbell and David Blumenthal

Fraud, fabrication, and falsification by David B. Resnik

Obligation to publish and disseminate results by Drummond Rennie.

ISBN

9780195168655

0195168658

Language

English

Material Type

Book

Audience

Professional

Location

Vancouver Library

Kelowna Library

Surrey Library

Victoria Library

Abbotsford Library

Call Number

W20.55 H9 O98 2008

Copies

Author

Ohh, Michael

Place of Publication

[Vancouver, BC?]

Publisher

Michael Ohh

Publication Date

1995

Subjects

Gene Expression Regulation

Cell Adhesion Molecules

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QH506 O37 1995

Copies

Author

Chiu, Roland K

Place of Publication

[Vancouver, BC?]

Publisher

Roland Kenly Chiu

Publication Date

1995

Subjects

Antigens, CD44

Cell Adhesion

Hyaluronan

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QW570 C543 1995

Copies

Author

Pyszniak, Andrew M

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subjects

Lymphocyte Function-Associated Antigen-1

Antigens, CD18

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QZ202 P998 1997

Copies

Author

Kalesnikoff, Janet

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2003

Subjects

Mast Cells

Cell Division

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QZ202 K14 2003

Copies

Author

Maksakova, Irina Arielevna

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2008

Subjects

Terminal Repeat Sequences

Retroelements

Endogenous Retroviruses

Mice - genetics

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

LE3 2008 M235

Copies

Author

Ghaffari, Saghi

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1996

Subjects

Hematopoiesis

Antigens, CD44

Leukemia

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

WH140 G411 1996

Copies

Author

Krosl, Jana

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1997

Subjects

Erythropoietin

Receptors, Erythropoietin

Hematopoiesis

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

WH140 K93 1997

Copies

Author

Klinger, Mark

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2002

Subjects

Guanosine Triphosphate

GTP-Binding Proteins - physiology

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QU55 K65 2002

Copies

Author

Marwali, Muhammad Reza Perkasa

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1991

Subjects

Lymphocyte Function-Associated Antigen-1

Membrane Microdomains

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

LE3 1991 M391

Copies

Author

Ruschmann, Jens

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2009

Subjects

Hematopoiesis

Replication Protein C

Granulocyte-Macrophage Colony-Stimulating Factor

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

LE3 2009 R951

Copies

Author

Gaboury, Louis A.

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

1988

Subjects

Hematopoiesis

Growth Substances

Bone Marrow

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

WH140 G116 1988

Copies

Author

Landry, Josette-Renee

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2003

Subjects

Genes, Regulator

Endogenous Retroviruses

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

QH450 L262 2003

Copies

Author

Lai, Chieh Min

Place of Publication

[Vancouver, BC?]

Publisher

University of British Columbia

Publication Date

2012

Subjects

Killer Cells, Natural

Transcription, Genetic

Natural Cytotoxicity Triggering Receptor 1

NK Cell Lectin-Like Receptor Subfamily K

Language

English

Material Type

Book

Thesis

Audience

Professional

Location

Vancouver Library

Call Number

LE3 2012 L185

Copies

Author

Angell, Marcia

Edition

updated ed.

Place of Publication

New York, NY

Publisher

Random House Trade Paperbacks

Publication Date

2005

Physical Description

xxviii, 319p. ; 21 cm.

Subjects

Drug Industry - economics

Advertising as Topic

Pharmaceutical Preparations - economics

Biomedical Research - economics

Government Regulation

Marketing of Health Services

United States

Abstract

The $200 billion colossus -- The creation of a new drug -- How much does the pharmaceutical industry really spend on R & D? -- Just how innovative is this industry? -- "Me-too" drugs : the main business of the pharmaceutical industry -- How good are new drugs? -- The hard sell...lures, bribes, and kickbacks -- Marketing masquerading as education -- Marketing masquerading as research -- Patent games : stretching out monopolies -- Buying influence : how the industry makes sure it gets its way -- Is the party over? -- How to save the pharmaceutical industry...and get our money's worth.

ISBN

9780375760945

0375760946

Language

English

Material Type

Book

Audience

Professional

Location

Vancouver Library

Call Number

QV736 A583t 2005

Copies